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Fast Dissolving Pellets
Introduction
Conventional solid dosage forms such as tablets or hard gelatine capsules are mostly taken intact with water or any other suitable liquid. In contrast to these preparations, fast dissolving oral drug products are administered without any liquid at all. The API is delivered upon instantaneous disintegration and/or dissolution of the dosage form without co-administered liquid; absorption of the API occurs locally and/or in the deeper segments of the gastro-intestinal tract. Fast dissolving preparations are ideal dosage forms for patients who have distinct difficulties in swallowing conventional dosage forms.
Fast Dissolving Pellets
Our fast dissolving products are designed as multiple-unit systems, which consist of several thousand spherical particles. These Fast Dissolving Pellets are manufactured using proprietary pelletisation techniques. Fast Dissolving Pellets consist entirely of very water soluble and/or swellable excipients and can be compressed into orally dispersible tablets (ODTs). The typical features of our Fast Dissolving Pellets can be summarised as follows:
- Narrow particle size distribution, e.g. 100 - 400 µm
- Smooth mouthfeel
- Highly water soluble & swellable pharmacopoeial constituents with low hygroscopic behaviour
- Addition of flavouring agents possible
- Spherical pellets with porous structure; porosity facilitates disintegration and dissolution
- Mechanically very stable; easy product handling
- Packaging into conventional stick packs feasible
- Pellets can be compressed into oral dispersible tablets (ODTs)
The dissolution behaviour of typical Fast Dissolving Pellets, e.g. containing Loperamide and Zopiclone as APIs, is depicted below. The SEMs reveal the porous structure of Fast Dissolving Pellets, which facilitates and ensures instant disintegration and dissolution.
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